具有类脑功能的神经形态器件可以动态模拟神经元行为，其中基于两端忆阻器的神经形态器件已经广泛应用于脑机接口、神经形态计算等领域。然而，固态器件的忆阻器难以模拟生物突触，因此需要开发液相环境以离子为载流子的流体忆阻器，以便实现类脑神经形态功能。金属有机框架材料具有高孔隙率、易功能化等优势，已广泛应用于构筑基于离子传输的流体器件。其中，光响应的流体功能器件引起了研究者的广泛关注。本工作通过在玻璃微米管的尖端原位生长包裹螺吡喃分子的UiO-66 MOF材料，成功构筑了一种具有光响应的流体忆阻器。通过施加紫外光照可以增强流体忆阻器的记忆效应，加入L-半胱氨酸分子后可进一步调控该忆阻器的离子传输性能，为活体电化学传感检测提供了一种新的原理和方法。

Neuromorphic devices with brain-like functions can dynamically simulate the behavior of neurons, of which neuromorphic devices based on the two-terminal memristors have been widely used in brain-machine interface and neuromorphic computing. However, it is difficult for memristors based on solid-state devices to simulate biological synapses. Therefore, it is necessary to develop fluidic memristors with ions as carriers in the liquid phase to realize brain-like neuromorphic functions. Metal-organic frameworks (MOFs) have been widely used in the construction of fluidic devices based on ion transport given the merits of high porosity and easy functionalization. Among them, photo-responsive fluidic devices have attracted extensive attentions. In this work, we constructed a photo-responsive fluidic memristor by in-situ growth of UiO-66 MOF encapsulated with spiropyrans inside the tip of a glass micropipette. We found that the memory effect of the fluidic memristor can be enhanced after irradiation of ultraviolet light. Meanwhile, the ion transport performance can be further regulated by adding L-cysteine, which may provide a new principle and method for electrochemical sensing in vivo.