本论文以β-二羰基化合物为底物，在手性伯胺和光催化剂钌配合物的协同催化下，在空气中用蓝光光照，实现了β-二羰基化合物的不对称α-羟基化反应。反应具有良好的产率和优异的对映选择性。反应可适用于多种β-酮酯、β-酮酰胺类底物，适用范围广泛。反应产物可发生衍生化反应，说明此方法在不对称合成中具有一定的应用潜力。

In this thesis, the asymmetric α-hydroxylation of β-dicarbonyl compounds was realized by synergistic catalysis of chiral primary amine and ruthenium photocatalyst under blue light with good conversion and excellent enantioselectivities. This type of reaction system can be applied to a wide range of β-ketoesters and β-ketoamides. The products obtained could be derived to important synthetic synthons, which indicates potential application in the asymmetric synthesis of complicated natural products.