定位导航是动物长期进化过程中形成的重要行为，准确的定位导航对于 动物觅食、归巢、社交和迁移等生命活动十分重要。大脑中的海马结构被认 为在定位导航中发挥着重要的作用，其中海马区的位置细胞通过编码动物所 在位置的信息，协助动物完成空间导航。然而当动物面临一个较为复杂的空 间任务，如迷宫时，位置细胞如何帮助个体学习和记忆正确的路径尚不清楚。 因此本课题通过利用钙成像技术，记录小鼠在学习迷宫过程中其海马区细胞 放电的情况，从群体水平上研究学习过程中位置细胞的编码变化。结果表明 学习过程中发生着大量的细胞变化，经过一段时间的学习后，位置细胞的空 间放电特异性提高，最终一定数量的细胞可以很好的表征正确的迷宫路径。 这一发现将进一步补充和扩展海马细胞在空间学习中的特征和功能。 

Navigation is an essential part of daily life, in which subject migrates from the start to the end of each journey. The hippocampal formation in the brain plays an important role in navigation, in which selective coding of space is process by hippocampal place cells. However how do place cells help the individual to learn and remember the correct path when animals are solving a complex spatial task such as maze is unknown. So this project studied the dynamic coding of spatial positions of hippocampal place cells at population level during a complex maze learning. By using calcium imaging techniques to record the calcium event of cells in the hippocampus during maze learning, the results showed that a large number of cell changed their firing pattern during the learning process. With the continuous of learning, the spatial specificity of the place cells increased, and finally a certain number of cells could well represent the correct maze path. This preliminary result will help our understanding of the characteristics and functions of hippocampal cells in spatial learning.