高硫型抗生素废水是一种较难处理的高浓度有机废水，寻找经济高效的处理工艺成为近年来的研究重点。本文通过批量培养探讨微好氧（DO≤0.5mg/L）条件处理高硫高浓度抗生素废水的可行性，考察溶氧供给及pH调控对处理效果的影响；通过连续小试考察HRT与进水COD浓度对微好氧工艺污染物去除效果的影响；以臭氧工艺作为生物处理的后续工艺，考察臭氧投加量与调控初始pH对污染物去除效果的影响。结果表明：（1）微好氧和无氧条件下批量培养试验表明：微好氧条件下微生物活性较高，能有效去除COD（去除率为55%）；无氧条件下，COD几乎没有变化，MLSS的增长相当缓慢。（2）微好氧连续小试结果表明：当进水COD浓度为13000mg/L，HRT为96h时，COD去除率可达到60%，BOD的去除率为94.4%。提高进水COD浓度（16000mg/L）或缩短水力停留时间（HRT=65h）时，COD的去除率下降，分别为51%和45%。当进水COD浓度为13000mg/L，HRT由96h降至80h时，BOD的去除率降至67%。HRT为96h时，系统出现污泥分层现象，N、P的绝对去除量之比约为1：1。缩短HRT至65h时，N、P的绝对去除量之比约为6：1。试验中进水、曝气柱出水和沉淀柱出水中SO42-浓度，其浓度分别为（7318±415）、（7414±184）、（7338±274）mg/L，方差分析表明三者SO42-浓度没有显著性差异（P>0.842），说明在本研究中并不存在硫酸盐还原作用，（3）臭氧处理结果表明：在臭氧投加量为0-198mg/L时，废水中BOD/COD出现上升(由0.22上升到0.29)，继续增加臭氧投加量，BOD/COD下降。臭氧投加量为316mg/L时，COD去除率达到最大（29%），此时，土霉素的去除率为78%。臭氧投加量为806mg/L时，土霉素的去除率接近100%，此时色度去除率达到35.4%。COD的降解速率与土霉素的降解速率不同。

Sulfate-ridden high-strength fermentative industrial wastewater is treated difficultly. This paper attempts to treat the high-sulfur antibiotic wastewater by bacteria, take micro-aerobic (DO=0-0.5mg/L) operating conditions, and discussion on the effect biological treatment of antibiotic wastewater. A lab-scale continuous experiment was designed to investigate the effect of various influent COD Concentrations（13000、16000 mg/L）or HRTs (96、80、65h) on the biological treatment performance of the high-sulfur antibiotic wastewater.The treatment effect of ozone reaction are discussed in the paper by different ozone dosages. The following results were obtained from the experiments:⑴ Batch experiments show oxygen supply had an important effect on bacteria growth and COD removal, DO levels ≤0.5 mg/L, the microorganism grew well while COD removals were 55%, however, without oxygen supply, there was almost no COD removal. ⑵ In the continuous running at low DO levels, it achieved a COD removal of 60%,BOD5 removal of approximately 94.4% in the influent at 96 h HRT and influent COD level of 13000 mg/L. Orange removal decreased when shorten HRT from 96h to 65h or improve the influent COD from 13000 to 16000 mg/L.The ratio between TN and TP removal is different from HRT 96h to 65h. The results show that reduction process of sulfate is not existed under the microaerobic condition.⑶ The obtained results show that the ozonization pretreatment technique can improve the biochemical treatment effect in the ozone dosages of 0-198mg/L.The result of BOD/COD decreased when increased ozone dosage. The highest COD removal is 29% in the ozone dosage of 316mg/L. Oxytetracycline removal is close to 100% in the ozone dosage of 806mg/L,and then color removal is 35.4%.