本文使用模拟实验的方法，对响应曲面方法中较为常用的中心复合设计、Box-Behnken设计以及均匀外壳设计进行了比较研究。首先论述了几类响应曲面方法中设计方案的相关概念并阐释了模拟实验的实验思路，之后分别从因析设计、轴向距离、中心点的实验次数等方面进行调整，使用拟合优度及均方误差作为模型拟合效果的评判标准，对不同设计方案得到的模型的拟合效果进行了讨论，并得出结论，从而对现实当中的实验设计问题的优化提供一定的参考思路。

In this paper, the center composite design, Box-Behnken design and uniform shell design, which are commonly used in response surface method, are studied by simulation experiment. First we discussed several types of response surface method in relevant concepts and illustrates the simulation experiment of ideas, then respectively from for center of analysis design, the axial distance, to adjust the test times etc., use of goodness of fit and the mean square error (MSE) as the judgment standard of model fitting effect, the different design schemes of model fitting effect are discussed, and finally drawed the conclusion, which provides a reference for the optimization of experimental design problems in reality.