本文建立了吸附伏安法测定丁酰苯类药物〔氟啾定醇(Hal)、氟哌啶(Dro)和对氟-r-(4-二苯甲基哌嗪-1)-丁酰苯(FDB)的新方法，並研究了它们的电化学性质，特别是其吸附性。在氨性缓冲溶液中，Ha1、Dro和FDB均可在汞电极上还原，电子转移数ｎ=2。峰电位分别为-1.55ｖ、-1.46v和-1.43v(vs.饱和Ag／Agce).在选定的条件下，用吸附伏安法测定的检测限可分别达到22×10-9mol/L1×10-9mol/L和5×10-10/L。应用该方法测定了针剂、片剂和用药患者尿样中Hal和Dro的含量，结果较满意。Hal，Dro和FDB的电化学性质和吸附性质极其类似，其吸附均具有中性分子的吸附特征。它们的扩散态和吸附态均可还原，但二者的还原电位无法区分，故属于反应物弱吸附体系。只有在浓度较小，扫速较快，搅拌富集时间较长时，其还原才完全为吸附控制;可认为是不可逆吸附体系，并求得其电子转移系数２。根据饱和吸附量测得每个吸附的Hal、Dro和FDB分子所占电极面积分别为0.79nm2、1.48nm2和2.34nm2。

An Adsorptive Stripping Voltammetric- method has been deve-loped to determine butyrophenone compound Haloperidol (Hal)， Droperidol (Dro) and p-fluro-(4-diphenylmethylpiperazin〇-l-y-butyrophenone(FDB) their electrochemical characteristics have been studied. In NH^-NH^Cl supporting electrolyte, Hal, Dro an FDB can reduced on the mercury electrode. The reduction poten-tials are -1.55V, -1.40V and -1.43V (vs. Ag/AgCl) and Detectio Limits are 2.10-9 mol/L (60s accumulation). 1.10-9mol/L (90s accumulation ) and 510-10 mol/L (30Os accumulation),respectely By using this method, we have determined Hal and Dro in the saple of injection, tablet and urine. The results are satisfacto Their electrochemical and adsorptive characteristics are very milar. Their adsorptive characteristics are of neutral molecul Their diffusive molecules and adsorptive molecules can be redu ced on electrdde, but these .;two reduction potentials can not b distinguished* So they belong to reactant week adsorptive syst Only when the concentration is small, the sweep rate is big, taccumulation time is long, are their reductions completely con troled by adsorption. It can be thought as irreversible adsorp tive system. The electron transfer coefficient a were obtained The electrode area occupied by every adsorptive molecules was caculated to be 0.79nm2, 1.48nm2 and 2.34nm2 on the basis of s turated adsorptive capacity.