本文成功地研究了4-取代苯基-3,5-双甲酯基-2-异噁唑新的合成方法,并对取代苯基硝酮与 5-冰片氧基-2(5H)-呋喃酮的[3+2]环加成反应进行了初步研究。 实验结果表明:4-取代苯基 3,5-双甲酯基-2-异恶唑啉-N- 氧化物发生热解反应形成了新的杂环化合物:4-取代苯基-3,5-双甲酯基-2-异噁唑,产率43-81%。 取代苯基硝酮与5-冰片氧基-2 (5H)-呋喃酮可发生环加成反应,总产率>90%。产物得到初步分离,尚待进一步分离纯化。 本文共合成了10 个新的化合物,经元素分析,IR,HNMR,"CNMR,MS 确证了所有化合物的结构。本论文开拓了4-取代苯基-3,5-双甲酯基-2-异噁唑类杂环化合物合成的新方法,并为合成具有生物活性的天然产物、药物提供了新途径。

This studies have been successfully carried out the new synthetic method of 4-substituted phenyl-3,5-bis(methoxycarbonyl)-2-isoxazole, and researched the [3+2] cycloaddition reaction of substituted phenyl nitrone with 5-bornyloxy-2(5H)-furanone. The experimental reasults demonstrate that these heat decomposing reactions can take place with yeilds of 43-81%,Which provided a series of novel heterocyclic 4-substituted phenyl-3,5-bis(methoxycarbonyl)- 2-isoxazoles. The cycloaddition of substituted phenyl nitrone with 5- bornyloxy-2(5H)furanone can take place with >90% total yields. The products have been separated preliminarilly . 10 new compounds have been synthesized, all of them are identifited on the basis of their analytical data and spectroscopic data such as elementary analysis ,IR,'HNMR,13CNMR, and MS. The accomplacement of this paper develops new synthetic method of isoxazoles and provides an effective route to the synthesis of biological active natural products and medicines.