6-氟色满-2-羧酸是制备新型抗高血压药奈必洛尔的关键中间体，本文使用4-氟苯酚为原料，经过甲基化、Friedel-Crafts酰基化合成4-(4-氟-2-苯酚)-4-氧代-2-丁烯酸。后者与(S)-α-苯乙胺反应得到相应酰胺，再在碱性条件下环化，最终经过催化氢化、水解等一系列反应得到具有光学活性的6-氟色满-2-羧酸。

6-Fluorochroman-2-carboxylic acid is a key intermediate of the synthesis of Nebivolol, a new antihypertensive agent. In this article (E)-4-(5-fluoro-2-hydroxyphenyl)-4-oxobut-2-enoic acid was prepared from 4-fluorophenol by methylation and subsequent Friedel-Crafts acylation. The acid reacted with (S)-α-Phenylethylamine to give the corresponding amide which cyclized in basic condition. Finally hydrogenation and hydrolysis achieved optical activity 6-fluorochroman-2-carboxylic acid.