本文研究了甲硝唑、盐酸尼卡地平和阿霉素在钴离子注人的玻碳电极(Co/GC)上的电化学行为及其电极反应机理,建立了以线性扫描伏安法测定该三种药物的新方法。 甲硝唑在0.1 mol/L KCl+0.02 mol/LHC1溶液中，用注入钴的玻碳电极作为工作电极进行测定，形成良好的还原峰，峰电位为Ep=-0.679V(vs.SCE)。测定的线性范围为4.0x 10-7 ~ 1.0 x 10-4mol/L，检出限为2.0 x 10-7mol/L。并用于分析片剂中甲硝唑的含量，回收率在94.0~ 104.2%之间。 盐酸尼卡地平在0.02 mol/LB-R 缓冲溶液中(pH=5.52)，用注人钴的玻碳电极作为工作电极进行伏安测定，形成一良好的还原峰，峰电位 Ep=-0.816V(vs.SCE)。峰电流与盐酸尼卡地平浓度在4.0 x 10-7~ 1.0 x 10-4mol/L范围内成线性关系，检出限为1.0x 10-7mol/L。用于片剂测定，得到满意的结果。 阿霉素在0.1mol/LHAc-NaAc缓冲溶液中(pH=4.62)，用注入钴的玻碳电极作为工作电极进行伏安测定，形成一良好的还原峰，峰电位 Ep=-0.522V(vs.SCE)。峰电流与阿霉素浓度在1.4x10-7~1.4x 10-6mol/L和2.8x 10-6- 5.6 x 10-5mol/L范围内成线性关系，检出限为5.0 x10-8mol/L。 用循环伏安法研究了这三种物 质的电化学行为及其反应机理，认为甲硝唑、盐酸尼卡地平属不可逆波，阿霉素为可逆波。对于甲硝唑、盐酸尼卡地平和阿霉素的电极反应主要受扩散控制。 用俄歇电子能谱(AES)和光电子能谱(XPS)两种表面分析技术检测了注人电极表面的元素组成、价态和深度分布情况，对离子注入电极的一些性质进行了初步探讨。

In this paper,the new methods of metronidazole、nicardipine hydrochloride and adriamycin have been established for the determination by linear-sweep voltammetry at Co ion implantation modified electrode,and their electrochemical behaviours have been studied. With Co/GC ion implantation modified electrodes as working electrode,in 0.1mol/L KC1+0.02mol/L HCl solution,a sensitive reduction wave of metronidazole was obtained.The peak potential was -0.679V(vs.SCE).The peak current was proportional to the concentration of metronidazole over the range of 4.0 x 10-7 ~ 1.0 x 10-4mol/L with the detection limit of 2.0 x 10~mol/L.The behaviour of the reduction wave was studied and applied to the determination of metronidazole in tablet.The reduction process was irreversible and diffusion-controlled. With Co/GC ion implantation modified electrode as working electrode,in 0.02mol/L B-R buffer solution,a sensitive reductive wave of nicardipine hydrochloride was obtained.The peak potential was -0.816V(vs.SCE).The peak current was proportional to the concentration of nicardipine over the range of 4.0 x 107~1.0 x 10-4mol/L and the detection limit was 1.0 x 10~mol/L.This method was applied to the determination of tablet.The reduction process irreversible and diffusion-controlled. With Co/GC electrode as working electrode,in 0.1mol/L NaAc- HAc buffer solution,a sensitive reductive wave of adriamycin was obtained.The peak potential was -0.522V(vs.SCE).The peak current was proportional to the concentration of adriamycin over the range of 1.4 x 10-7 ~ 1.4 x 10-6mol/Land 2.8 x 10-6 ~ 5.6 x 10-5mol/L.The detection limit was 5.0 x 10-8mol/L.The reduction process was reversible and diffusion-controlled. The experiments of AES and XPS showed that Co was surely implanted into the surface of the GCE and the implanted Co improved the electrochemical activity of the GCE.