医护人员的身体和心理都面临着来自职业和外界的多重压力，而他们的工作投入水平具有重大意义，不但直接影响工作绩效和患者健康，甚至关系到国家整体医疗服务水平，如何抗住压力、投入工作，自身心理弹性的作用至关重要。同时，疫情的重大压力下医护人员在岗位上的担当、坚韧和奉献，以及强烈的工作意义感，令人敬佩，更启示了这一群体的职业使命感的特殊影响。

基于以上背景和观察，以及自我决定理论和职业生涯构建理论，本研究旨在探究医护人员的职业使命感对工作投入的影响及其作用路径，提出将工作意义感和心理弹性作为中介变量，并基于积极情绪的拓展-构建理论，考察工作意义感、心理弹性在二者间的链式中介效应。研究采用问卷调查法，调查医护人员的职业使命感、工作意义感、心理弹性和工作投入等真实感受和表现，共收集301份样本数据。再通过SPSS和其中process宏程序进行数据的统计分析，对模型中变量展开差异性检验、回归分析和中介效应检验等。

通过实证研究得出结论：医护人员的职业使命感在年龄、工作年限、婚姻状况方面差异显著，工作意义感和工作投入在工作年限方面差异显著，心理弹性在工作年限、工作性质和婚姻状况方面差异显著；职业使命感显著正向作用于工作投入，工作意义感和心理弹性分别在两者之间起部分中介作用，即职业使命感可以通过工作意义感影响工作投入，也可以通过心理弹性影响工作投入，同时，工作意义感-心理弹性还在职业使命感与工作投入之间起链式中介作用。最后，根据研究结果，分别从三个影响因素的角度为改善医护人员的工作投入提出建议，并针对本研究局限作出未来展望。

Medical staff are faced with much physical and mental pressure from occupation and the outside world, meanwhile their level of work engagement has a significant effect. As to how to withstand pressure and improve work engagement, their mental resilience is crucial. On the other hand, during the recently epidemic period, the sense of responsibility, tenacity and devotion, as well as the strong sense of job meaning of medical staff further revealed the special influence of their occupational calling on work engagement. Based on such background and observation, this study took the sense of job meaning and mental resilience as mediating variables to explore the influence path between occupational calling and job engagement of medical staff. Through regression analysis and mediating effect test, the conclusions were drawn: The occupational calling of medical staff has a significant positive effect on work engagement. The sense of job meaning and mental resilience play a chain intermediary role between the two. Finally, suggestions were put forward from the three paths for improving work engagement of medical staff.