创新是企业发展和国家经济进步的重要因素，企业在创新活动中的地位日益显著，国内外许多学者就企业规模对创新活动的作用机制进行了理论和实证研究。本文采用2001-2010我国主板市场上市公司为样本，根据专利类型赋予不同权重构建专利产出指标，全面衡量公司创新成果。结合公司其他数据，应用固定效应模型对我国企业规模与专利产出之间的关系进行实证分析。本文的基本研究发现，上市公司专利活动与公司规模呈现倒“U”型非线性关系，专利产出具有明显的累积效应，公司每股经营活动净现金流越大有利于公司创新活动，地区金融发展对不同性质企业的影响不同。最后，我们从企业和政府政策两个层面提出建议。

Innovation is the key factor of enterprise development and the whole economics progress, and enterprise enjoys increasingly important role and high status on the innovative activity. Many scholars at home and abroad research the mechanism of the scale to the enterprise innovation ability by theory and practice. Using main board listed companies as the sample from 2001 to 2010, this paper build a new index to entirely measure the innovative output by giving different weights to patents depending on the type. With other firm-level data, we apply fixed-effect model to analyzing the relationship of enterprise scale and innovative output. After some regressions, this paper find that there is an inverse U relationship between firm size and technological innovation of listed companies, and the effect of patents accumulating is positive. Secondly, large company operating activities net cash flow per share is beneficial to the enterprise innovation. Thirdly, financial development has a different influence on the firms due to their ownership. In the end, we put forward some suggestion for both enterprise and government.