本论文主要研究的是测定候选药物的脂肪/水、蛋白质/水的分配系数。本论文具体研究工作如下： 1、介绍了药物在人体内吸收、分布、代谢、排泄的过程以及药物的体外ADME模型研究进展。 2、人体的大部分组织和器官主要是由脂肪、蛋白质和水组成，药物在各个器官吸收和分布的不同主要由该器官所含脂肪、蛋白质和水的量的不同决定，与他们在哪个组织器官无关。因此认为药物在人体各器官的含量可以看成是药物在这三种组织成分中分布量之和。以此为根据，建立了一个药物分布的体外模型。这是一个非线性方程。运用它可以计算出候选药物在人体七个器官中的器官（组织）浓度/血药浓度的分配系数。数据包含了11种分布于人体大脑、肌肉、肺、肾脏、肝脏、心脏和脂肪组织中的药物。共有32个数据点。最终得到模型的计算值与文献参考值有r=0.8713的线性相关度。

This thesis mainly research is to measure the drug candidates fat/water, protein/water distribution coefficient. This thesis concrete research work is as follows: 1. Summarizes the present situation of the research and drugs in the human body absorption, distribution, metabolism and excretion process, introduces the Progress of research In Vitro Models Used to Screen for Human ADME Drug Properties. 2. Most of the tissues and organs of the human body is mainly by fat, protein and water composition, drugs in various organs absorption and distribution by the organs of different major contain fat, protein and the amount of water, and the differences in their decision which tissues and organs is irrelevant. In this work, the tissue/blood partition coefficients of seven human tissues were calculated using a nonlinear regression analysis. The dataset contained 11 drugs structurally diverse compounds distributing into the brain, kidney, muscle, lung, liver, heart, and fat. A total of 32 data points were there. The calculation value of the model has a good linear correlation(r=0.8173) with reference value.