近年来，随着人工智能、脑机交互等领域的兴起以及纳米技术的发展，纳米限域流体忆阻器成为神经形态功能器件开发的重点研究方向。金属有机框架（Metal-organic framework，MOF）是一种由金属离子或簇通过有机配体连接而形成的多孔晶体结构。MOF具有本征的亚纳米孔道、高度可设计的位点，因此基于MOF的纳米限域通道受到了广泛的关注。Hofmeister序列不仅适用于生物体系大分子，如酶活性、酶催化、氨基酸旋光性、细菌生长等行为分析，而且对水溶液中各种大分子体系的相行为、分子自组装调控、功能材料性能改进等也有一定的影响。本论文构筑了UiO-66-COOH修饰的玻璃微米管，发现UiO-66-COOH修饰的玻璃微米管可以模拟突触可塑性，包括双脉冲易化、双脉冲抑制、时间依赖可塑性等，进一步探究Hofmeister离子序列对流体忆阻器的类突触功能的调控，发现各离子电流大小和记忆时间（NH4+＞K+＞Na+＞Li+＞Ca2+）与Hofmeister序列基本一致。我们推测其机理，一方面可能是由于离子的尺寸大小差异引起离子电流的不同，另一方面可能是不同阳离子与材料羧基的静电相互作用导致记忆时间的不同。

In recent years, with the rise of artificial intelligence, brain-machine interfaces, and the development of nanotechnology, nanoconfined fluidic memristors have become a key research focus in the development of neuromorphic functional devices. Metal-organic framework (MOF) has porous crystalline structures formed by the connection of metal ions or clusters through organic ligands. MOF possesses intrinsic sub-nanometer pores and highly customizable sites, making nanoconfined channels based on MOFs widely studied. The Hofmeister sequence applies not only to macromolecules in biological systems, such as enzyme activity, enzyme catalysis, amino acid chirality, and bacterial growth analysis, but also affects the phase behavior of various macromolecular systems in aqueous solutions, molecular self-assembly regulation, and improvement of functional material properties. In this paper, micropipettes modified with UiO-66-COOH were investigated, and we found that the functional micropipettes modified with UiO-66-COOH can simulate synaptic plasticity, including paired-pulse facilitation (PPF), paired-pulse depression (PPD), and spiking-timing dependent plasticity (STDP). Further exploration of the regulation of synapse-like functions with fluidic memristor by the Hofmeister ion sequence revealed that the current magnitude with each kind of ions and memory time (NH4+ > K+ > Na+ > Li+ > Ca2+) are generally consistent with the Hofmeister sequence. We speculate on the mechanism that the differences in ion current may be caused by variations in ion size and different interactions between cations with carboxyl groups of MOF structures, which lead to the differences in memory time.