本研究旨在考察脑源性神经营养因子（BDNF）基因与5-羟色胺转运体（5-HTT）基因对人格特质的交互作用，进而探讨多基因如何相互作用，影响个体的人格特质。有证据表明BDNF基因和5-HTT基因多态性分别对个体的人格特质有影响。而近来有研究报道了不同的基因对人格特质有共同作用。本研究选取了447名大学生被试，采用气质性格问卷(TCI)，考察BDNF基因val66met多态性与5-HTTLPR多态性对人格特质的共同作用。结果发现，BDNF基因型对个体的伤害回避特质有作用，vv纯合子的伤害回避得分高于m携带者；而5-HTTLPR多态性会影响个体的伤害回避特质、坚持性特质、自我指向性特质，基因型为ss纯合子的个体的伤害回避、坚持性和自我指向性分量表的得分均高于l携带者。多元方差分析显示，在女性被试中，BDNF基因val66met多态性与5-HTTLPR多态性对自我指向性特质具有显著的交互作用。具体表现为，在5-HTTLPR基因型为l携带者的个体中，BDNF基因met携带者在自我指向性分量表的得分高于vv纯合子。该结果表明，BDNF基因和5-HTT基因对人格特质的多个方面有着稳定而复杂的影响。考察多基因对人格特质的影响尚需广泛深入的研究。

There is evidence for an association between genotype of Brain derived neurotrophic factor (BDNF) and personality traits, and association between serotonin transporter-linked promoter region (5-HTTLPR) gene polymorphism and personality traits, respectively. Recent findings have shown that interactions between allelic variants of the different genes may contribute to personality traits. We examined the effects of BDNF val66met and 5-HTTLPR polymorphisms for associations with the Temperament and Character Inventory-Revised version (TCI-R) in 447 Chinese college students. We found that the variants of BDNF influence the Harm Avoidance (HA) temperament subscale and Self directedness (SD) character subscale of TCI. And 5-HTTLPR polymorphism influence the HA and Persistence (PS) temperament subscales and SD character subscale of TCI. There is no interaction between the two genes in any subscale of TCI. Separating men and women apart, we found significant interactions between BDNF gene and 5-HTTLPR genes on Self directedness (SD) character subscales of TCI in female individuals. In the presence of the 5-HTTLPR l allele, subjects of group m of BDNF had a significantly higher SD score than those of group vv. These findings suggest that the variants of BDNF gene interacted with the 5-HTTLPR polymorphism to influence the SD character subscales of TCI, but only in female subjects.