1928年12月东北易帜，南京国民政府实现了对全国的统一。新疆远离内地，南京政府对之鞭长莫及。1928年新疆发生“七七政变”，金树仁上台执政。新疆政权交替之际，南京政府企图在新疆开展国民党党务以使中央势力逐渐渗透新疆，其结果失败。1933年发生“四·一二政变”，南京政府派黄慕松、罗文干入新宣慰均铩羽而归。南京政府筹谋对新疆善后和治理的办法虽皆告失败，但南京政府在与新疆直接或间接地接触过程中，对新疆情形有了更多了解，新疆民情也得以通达中央，此皆为日后国民党接管新疆统治奠定了基础。

December 29, 1928, Nanjing National Government achieve the unity of china in form. However, Xinjiang Province is so away from the mainland that beyond the reach of Nanjing National Government’s power. When the July 7 Coup of 1928 happened, Jing Shu-ren soon came to power in Xinjiang. Therefore, Nanjing National Government intend to seize the chance to control Xinjiang gradually by Party organizations in Xinjiang. But,it failed finally. When the April 12 Coup of 1933 happened, in order to settle combats and seize political power of Xinjiang, Nanjing National Government dispatch Huang Mu-song and Luo Wen-gan leave for Xinjiang. But it failed, and other methods failed yet. In the process, it contribute to mutual understanding between Nanjing National Government and Xinjiang ,and that lay the foundation for governing Xinjiang Province some time.