抑郁症是青年阶段最常见的心理障碍，也是致残和造成全球疾病负担的最主要原因。然而，目前对抑郁的病因探究并未能全面地防治抑郁障碍的发生发展。比如现有基于心理和生理的治疗方法在大学生群体的有效性存在差异化。深入探究抑郁症的病理生理机制，解析治疗过程中影响治疗效果的关键因素和路径，对于提高现有治疗的疗效，发展更有针对性的治疗方式至关重要。炎症假说提出炎症因子变化与抑郁症发生及发展密切相关，该机制也得到了实证研究的支持。然而，目前的相关研究大多关注确诊抑郁或炎症性疾病的患者，对于健康/亚健康人群的探究尚未充分，而且研究结果也不一致。在非临床人群中，慢性压力容易导致炎症水平的升高以及炎症状态的反复，这又与抑郁情绪和症状相关。基于此，不同炎症状态个体的抑郁干预效果可能存在差异。而且，研究非临床人群炎症与抑郁的相关以及潜在的干预方式，对于抑郁的早期防治有重要意义。正念干预对抑郁的改善效果已得到了理论和实证研究的支持，但正念缓解抑郁的生理机制并不明确。传统的正念干预在青年群体的干预效果可以通过虚拟现实（Virtual Reality, VR）技术得到加强，该技术克服了传统正念干预的长期效应差、场地时间成本高等局限性，然而，目前国内尚无研究将结合VR技术的正念干预方案应用于大学生群体中，其干预效果有待进一步检验。

因此本论文将设计一个结合VR技术的八周正念干预方案，通过随机对照试验来探究其对大学生的干预效果，并研究影响干预效果的关键炎症机制，验证炎症因子在正念干预和抑郁症状的关系中的作用。随机对照试验设置了干预组和控制组，其中，正念干预组（33人）接受八周正念干预训练，控制组（41人）不接受任何干预。干预前，两组通过自我报告和生理测量完成了抑郁症状、正念水平和炎症水平的基线前测，其中五因素正念量表测量被试的特质正念水平、抑郁自评量表测量被试的抑郁程度，免疫测定法测量主要炎症因子指标（IL-6, IL-8, TNF-α）的外周血浓度。干预完成，两组分别填写抑郁自评量表和正念五因素量表作为抑郁程度和特质正念水平的后测。

采用独立样本t检验，以组别（干预组VS.控制组）为自变量，后测与前测的特质正念水平差异值、后测与前测的抑郁程度的差异值为因变量进行差异检验；采用线性回归模型，以后测抑郁程度为因变量，组别（干预组VS.控制组）和前测炎症水平分别为自变量和调节变量，前测抑郁程度为控制变量进行调节效应检验，结果显示：首先，与控制组相比，结合VR技术的八周团体正念干预训练有效提升了个体的特质正念水平。但两组在抑郁程度上并未发现显著差异。其次，在正念干预影响抑郁症状的关系中，发现了炎症因子显著的调节效应：IL-1β与组别的交互项呈现出显著性，IL-6与组别的交互项呈现出显著性，TNF-α与组别的交互项不显著，这说明在正念干预对抑郁的干预效果可能被掩盖，而炎症因子的调节作用解析了正念干预对抑郁缓解效果：只有在IL-1β水平较高、IL-6水平较低的人群中，正念干预对抑郁症状的缓解作用是有效的。

综上所述，本研究说明了结合VR技术的八周团体正念干预训练对大学生抑郁症状的缓解对特定炎症状态的人群是有效的，正念干预对于IL-6水平较低和IL-1β水平较高的炎症状态人群具有更大的受益性。在理论层面上为正念的压力缓冲生物模型提供了实证支持及新的视角；在实践层面上为设计大学生的正念干预课程提供了新的思路。

Depressive disorder is the most common psychological disorder in youth and the leading cause of disability and the global burden of disease. However, the current study of the etiology of depression has not been able to comprehensively prevent the occurrence and development of depressive disorders. For example, the effectiveness of existing psychological- and physiologically-based therapies in the college student population is different. In-depth exploration of the pathophysiological mechanism of depression and analysis of the key factors and paths affecting the treatment effect during the treatment process are essential to improve the efficacy of existing treatments and develop more targeted treatment methods. The inflammation hypothesis proposes that changes in inflammatory factors are closely related to the occurrence and development of depression, and this mechanism is also supported by empirical studies. However, most of the current studies have focused on patients with confirmed depression or inflammatory disease, and healthy/sub-healthy populations have not been adequately explored, and the results are inconsistent. In non-clinical populations, chronic stress tends to lead to increased levels of inflammation and recurrent inflammatory states, which in turn are associated with depressed mood and symptoms. Based on this, the effects of depression interventions may vary in individuals with different inflammatory states. Moreover, studying the correlation between inflammation and depression in non-clinical populations and potential intervention methods is of great significance for the early prevention and treatment of depression. The improvement effect of mindfulness-based interventions on depression has been supported by theoretical and empirical studies, but the physiological mechanism of mindfulness to alleviate depression is not clear. The intervention effect of traditional mindfulness intervention in youth can be enhanced by virtual reality (VR) technology, which overcomes the limitations of traditional mindfulness intervention such as long-term effect difference and high venue time cost, however, there is no domestic study to apply mindfulness intervention program combined with VR technology to college students, and its intervention effect needs to be further tested.

Therefore, this paper will design an eight-week mindfulness intervention program combining VR technology, explore its intervention effect on college students through randomized controlled trials, and explore the key inflammatory mechanisms affecting the intervention effect, and verify the role of inflammatory factors in the relationship between mindfulness intervention and depressive symptoms. Randomised controlled trials set up intervention group and control group, in which the mindfulness intervention group (33 participants) received eight weeks of mindfulness intervention training and the control group (41 participants) received no intervention. Before the intervention, the two groups completed the baseline pre-test of depressive symptoms, mindfulness level and inflammation level through self-report and physiological measurements, in which the Five Facet Mindfulness Questionaire measured the participants' trait mindfulness level, the Self-Rating Depression Scale measured the participants' depression level and depression, and the immunoassay measured the peripheral blood concentration of the main inflammatory factor indicators (IL-6, IL-8, TNF-α). After the intervention was completed, the two groups filled in the Self-Rating Depression Scale as a post-test of depression level.

Using the linear regression model, the degree of depression in the post-test was the dependent variable, the pre-measured inflammation level and group (intervention group vs. control group) were independent variables and regulatory variables, respectively, and the pre-measured degree of depression was tested for the regulatory effect of the control variable, and the results showed that:

First，compared with the control group, the eight-week group mindfulness intervention training combined with VR technology effectively improved the individual's trait mindfulness level. However, no significant difference in depression was found between the two groups.Second, these results indicated a significant moderating effect of inflammatory factors in the relation between mindfulness intervention and depressive symptoms: the interaction of IL-1β and group had a significant effect on depressive symptoms, and the interaction of IL-6 and group had a significant effect on depressive symptoms, and the interaction of TNF-α and group on depressive symptoms were non-significant, which indicated that the effect of mindfulness intervention on depression may be masked, while the inflammatory factors moderate the effect of mindfulness intervention on depression symptoms. Only in people with higher IL-1β levels and lower IL-6 levels were mindfulness interventions effective in relieving depressive symptoms. Mindfulness-based interventions were more beneficial in people with low levels of IL-6 and high levels of IL-1β.

In conclusion, the present study sought to examine the moderating role of stress on susceptibility to inflammation-associated depressive symptoms among women with breast cancer followed over approximately 2 years. this study shows that the eight-week group mindfulness intervention training combined with VR technology is effective for the improvement of college students' trait mindfulness level for specific inflammatory states, and provides empirical support and new perspectives for the stress buffer biological model of mindfulness at the theoretical level. On a practical level, it provides new ideas for designing mindfulness intervention courses for college students.