心血管疾病已经发展成为危害人类身体健康的重大疾病，发展一种^99mTc标记的脂肪酸心肌代谢显像剂实现在分子水平对心血管疾病的早期诊断具有十分重要的意义。

在这篇论文中，前期合成的7个不同短碳链的标记化合物前体以铼/锝羰基核与铼/锝六配位两种形式参与配位，得到14种放射性标记化合物与14种非放射性标准品，通过对HPLC纯化后的放射性标记化合物进行电泳实验、脂水分配系数实验、体外稳定性实验以及小鼠体内生物分布等实验分析标记化合物在心肌中的摄取滞留情况。实验数据表明：14种标记化合物均是带正电荷的脂溶性化合物，在小鼠体内分布实验中均体现出肝本底较高的情况，与此同时，标记化合物7f具有较高的心肌初始摄取(4.34%ID/g)，化合物8f的具有不仅较高的心肌初始摄取(3.21%ID/g)，而且血液清除速率(血_1min/血_60min=60.84)、心肌滞留时间均表现出相对良好的优势，为发展^99mTc标记的脂肪酸心肌代谢显像剂提供新的思路。

Cardiovascular disease has developed into one of the major diseases that endanger human health. The development of a ^99mTc-labeled fatty acid myocardial metabolism imaging agent is very important for the early diagnosis of cardiovascular disease at the molecular level.

In this paper, seven compounds with different short carbon chains were synthesized to coordinate with ^99mTc(CO) and Tc core, and 14 radiolabeled compounds and 14 non-radioactive standards were obtained. The radiolabeled compounds purified by HPLC were subjected to electrophoresis experiments, lipid-water partition coefficient experiments, in vitro stability experiments, and biodistribution experiments in mice to analyze the uptake and retention of labeled compounds in the myocardium. The experimental data show that the 14 labeled compounds are all positively charged hydrophobic compounds, and the liver background is higher in the distribution experiment in mice. At the same time, the labeled compound 7f has a higher initial myocardial uptake (4.34% ID/g), while compound 8f had a higher initial myocardial uptake (3.21% ID/g), the blood clearance rate (blood_1min / blood_60min = 60.84) and myocardial retention time showed relatively good advantages, these data provide new ideas for the development of  ^99mTc labeled fatty acid myocardial metabolism imaging agent.