| 中文题名： | 具有AIE荧光示踪的谷胱甘肽刺激响应药物载体的设计合成 |
| 姓名： | |
| 保密级别： | 公开 |
| 论文语种： | 中文 |
| 学科代码： | 070301 |
| 学科专业： | |
| 学生类型： | 学士 |
| 学位： | 理学学士 |
| 学位年度： | 2022 |
| 学校： | 北京师范大学 |
| 校区： | |
| 学院： | |
| 第一导师姓名： | |
| 第一导师单位： | |
| 提交日期： | 2022-06-23 |
| 答辩日期： | 2022-06-23 |
| 外文题名： | Design and synthesis of a glutathione-stimulated responsive drug carrier with AIE fluorescent tracer |
| 中文关键词： | |
| 外文关键词： | Glutathionase ; redox stimulus response ; drug delivery ; fluorescent tracer |
| 中文摘要： |
癌细胞通常在许多方面与正常细胞不同，如缺氧、具有相对较低的pH值、活性氧（ROS）的过度产生和酶的过度表达等。因此，近年来对癌细胞微环境刺激响应的纳米载药系统的研究受到了人们极大的关注。本论文在文献调研和了解课题组前期工作的基础上，设计了一种以二硫键为刺激响应单元的两亲性聚合物作为药物载体。论文工作中以不对称四苯乙烯化合物为原料，通过碳碳偶联反应、醛与活泼氢的缩合反应、分步酯化反应，利用两个酯键将二硫键单元与四苯乙烯疏水AIE荧光单元和PEG链亲水单元连接起来，制备得到了两亲性目标分子TSP。对目标化合物TSP及其关键中间体进行了一定的结构表征。初步光谱研究表明了目标化合物TSP具有AIE性能，在3.09 μM浓度下可以形成胶束，有望成为对谷胱甘肽酶具有刺激响应的药物载体。最后对论文工作进行了总结和展望。
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| 外文摘要： |
Cancer cells often differ from normal cells in many ways, such as hypoxia, relatively low pH, overproduction of reactive oxygen species (ROS), and overexpression of enzymes. Therefore, research on nano-drug delivery systems in response to stimuli in the microenvironment of cancer cells has received great attention in recent years. In this paper, on the basis of literature research and understanding of the previous work of the research group, an amphiphilic polymer with a disulfide bond as a stimulus-responsive unit was designed as a drug carrier. In the work of the thesis, using asymmetric tetrastyrene compound as raw material, through carbon-carbon coupling reaction, condensation reaction of aldehyde and active hydrogen, and step-by-step esterification reaction, two ester bonds are used to connect the disulfide bond unit with tetrastyrene hydrophobic AIE. The fluorescent unit and the hydrophilic unit of the PEG chain are connected to prepare the amphiphilic target molecule TSP. The target compound TSP and its key intermediates were characterized. Preliminary spectroscopic studies have shown that the target compound TSP has AIE properties and can form micelles at a concentration of 3.09 μM, which is expected to be a drug carrier responsive to glutathione. Finally, the work of the thesis is summarized and prospected.
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| 参考文献总数： | 26 |
| 插图总数： | 24 |
| 插表总数： | 0 |
| 馆藏号： | 本070301/22065 |
| 开放日期： | 2023-06-23 |
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